C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 309/10 (2006.01) A61K 31/351 (2006.01)
Patent
CA 2645638
Glucopyranosyl- substituted, benzonitrile derivatives defined according to formula I, including the tautomers, the stereoisomers thereof, the mixtures thereof and the salts thereof . The compounds according to the invention are suitable for the treatment of metabolic disorders. formula (I), wherein R3 denotes hydrogen, fluorine, chlorine, bromine, iodine, methyl, ethyl, propyl, \ isopropyl, butyl, sec-butyl, iso-butyl, tert-butyl, 3-methyl-but-1-yl, cyclopropyl, \ cyclobutyl, cyclopentyl, cyclohexyl, 1-hydroxy-cyclopropyl, 1-hydroxy-cyclobutyl, 1- hydroxy-cyclopentyl, 1 -hydroxy-cyclohexyl, difluoromethyl, trifluoromethyl, pentafluoroethyl,_2-hydroxyl-ethyl, hydroxymethyl, 3-hydroxy-propyl, 2-hydroxy-2- methyl-prop-1-yl, 3-hydroxy-3-methyl-but-1-yl, 1-hydroxy-1 -methyl-ethyl, 2,2,2- trifluoro-1-hydroxy-1 -methyl-ethyl, 2,2,2-trifluoro-i-hydroxy-i-trifluoromethyl-ethyl, 2- methoxy-ethyl, 2-ethoxy-ethyl, hydroxy, difiuoromethyloxy, trifluoromethyloxy, 2- methyloxy-ethyloxy, methylsulfanyl, methylsulfinyl, methlysulfonyl, ethylsulfinyl, ethylsulfonyl, trimethylsilyl or cyano,
L'invention concerne des dérivés benzonitrile substitués par glucopyranosyle répondant à la formule (I), ainsi que leurs tautomères, stéréoisomères, mélanges et sels. Les composés selon l'invention sont utiles pour traiter les troubles du métabolisme. Dans la formule (I), R3 représente un atome d'hydrogène, de fluor, de chlore, de brome, d'iode ou un groupe méthyle, éthyle, propyle, isopropyle, butyle, sec-butyle, iso-butyle, tert-butyle, 3-méthylbut-1-yle, cyclopropyle, cyclobutyle, cyclopentyle, cyclohexyle, 1-hydroxycyclopropyle, 1-hydroxycyclobutyle, 1- hydroxycyclopentyle, 1-hydroxycyclohexyle, difluorométhyle, trifluorométhyle, pentafluoroéthyle, 2-hydroxyléthyle, hydroxyméthyle, 3-hydroxypropyle, 2-hydroxy-2-méthylprop-1-yle, 3-hydroxy-3-méthylbut-1-yle, 1-hydroxy-1 -methyléthyle, 2,2,2-trifluoro-1-hydroxy-1-méthyléthyle, 2,2,2-trifluoro-1-hydroxy-1-trifluorométhyléthyle, 2-méthoxyéthyle, 2-éthoxyéthyle, hydroxyle, difluorométhyloxy, trifluorométhyloxy, 2-méthyloxyéthyloxy, méthylsulfanyle, méthylsulfinyle, méthylsulfonyle, éthylsulfinyle, éthylsulfonyle, triméthylsilyle ou cyano.
Eckhardt Matthias
Eickelmann Peter
Himmelsbach Frank
Sauer Achim
Thomas Leo
Boehringer Ingelheim International Gmbh
Fetherstonhaugh & Co.
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