C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 15/203 (2006.01) A61K 31/7034 (2006.01) A61P 7/12 (2006.01)
Patent
CA 2548353
The invention relates to glucopyranosyloxy-substituted aromates of general formula (I), wherein R1 to R6 and R7a, R7b, R7c are defined according to patent claim 1. The invention also relates to the tautomers, stereoisomers, mixtures and salts of said aromates, especially the physiologically compatible salts comprising inorganic or organic acids and having valuable pharmacological properties, especially an inhibiting effect on the sodium- dependent glucose cotransporter SGLT2. The invention further relates to the treatment of diseases, especially metabolic diseases such as diabetes, and to the production of said compounds.
L'invention concerne des composés aromatiques à substitution glucopyranosyloxy de formule générale (I), dont les restes R1 à R6 ainsi que R7a, R7b et R7c sont définis dans la revendication 1. L'invention concerne également les tautomères de ces composés, leurs stéréo-isomères, leurs mélanges et leurs sels, notamment leurs sels physiologiquement compatibles comprenant des acides inorganiques ou organiques et présentant des propriétés pharmacologiques intéressantes, notamment un effet inhibiteur sur le cotransporteur de glucose sodium-dépendant SGLT2. L'invention concerne en outre l'utilisation de ces composés pour traiter des maladies, notamment des maladies métaboliques comme le diabète, ainsi que la production de ces composés.
Barsoumian Edward Leon
Eickelmann Peter
Himmelsbach Frank
Boehringer Ingelheim International Gmbh
Fetherstonhaugh & Co.
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