C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 17/02 (2006.01) A61K 31/7056 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) C07D 231/20 (2006.01)
Patent
CA 2382480
The present invention relates to glucopyranosyloxy- pyrazole derivatives represented by the general formula: Image wherein R1 represents a hydrogen atom or a lower alkyl group; one of Q1 and T1 represents a group represented by the general formula: Image while the other represents a lower alkyl group or a halo ( lower alkyl) group; and R2 represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a lower alkylthio group, a halo(lower alkyl) group or a halogen atom, or pharmaceutically acceptable salts thereof, which have an inhibitory activity in human SGLT2 and are useful as agents for the prevention or treatment of diabetes, diabetic complications or obesity, and to pharmaceutical compositions comprising the same and intermediates thereof.
L'invention concerne des dérivés de glucopyranosyloxypyrazole représentés par la formule générale (I) ci-après ou leurs sels pharmaceutiquement acceptables, lesquels dérivés ont un effet inhibiteur sur l'activité du SGLT2 humain et sont utiles comme agents préventifs ou comme remèdes contre le diabète, les complications du diabète ou l'obésité. Dans la formule (I), R<1> représente hydrogène ou un alkyle inférieur; Q<1> ou T<1> représente un groupe de formule (A), l'autre représentant un alkyle inférieur ou un alkyle inférieur halogéné; et R<2> représente hydrogène, un alkyle inférieur, un alcoxy inférieur, un alkylthio inférieur, un alkyle inférieur halogéné ou un halogéno.
Fujikura Hideki
Fujioka Minoru
Hiratochi Masahiro
Isaji Masayuki
Iyobe Akira
Kirby Eades Gale Baker
Kissei Pharmaceutical Co. Ltd.
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