C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 19/26 (2006.01) A61K 31/70 (2006.01) A61K 39/39 (2006.01) C07H 11/04 (2006.01) C07H 13/06 (2006.01) C07H 15/04 (2006.01)
Patent
CA 2175375
The invention relates to .beta.(16) glucosamine disaccharides having general formula (I) to a method for preparing these disaccharides, comprising the steps of: i) providing a starting material comprising lipid A moiety of lipopolysaccharide-comprising microorganisms; and ii) subjecting the starting material to an alkaline treatment such that lipid A moiety is O-deacylated at the 3-position and at the 3'-position, to pharmaceutical compositions comprising as an active ingredient these disaccharides, and to these disaccharides for use as an immunomodulating agent, anti-tumor agent, and vaccine component.
L'invention concerne des .beta.(1?6) disaccharides de glucosamine de formule générale (I) ainsi qu'un procédé qui permet de préparer ces disaccharides, et consiste à: i) fournir une matière de départ comprenant la fraction lipidique A de micro-organismes comprenant des lipopolysaccharides; ii) soumettre cette matière de départ à un traitement alcalin tel que la fraction lipidique A est O-déacylatée aux positions 3 et 3'. L'invention concerne aussi des compositions pharmaceutiques comprenant des dissacharides en tant qu'ingrédient actif, et ces dissacharides destinés à être utilisés comme agent immuno-modulateur ou anti-tumoral, ou comme composant de vaccin.
Bauer Jacques
Davies John Gwynfor
Hirt Pierre
Schulthess Adrian
Deutsche Om Arzneimittel Gmbh
Fetherstonhaugh & Co.
Laboratoires Om S.a.
Om Pharma
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