Glucosamine-peptide derivatives, their production and use

Details Glucosamine-peptide derivatives, their production and use Glucosamine-peptide derivatives, their production and use

C - Chemistry, Metallurgy

07

K

530/9, 167/103.8

C07K 9/00 (2006.01)

Patent

CA 1239636

Abstract of the Disclosure Novel glucosamine-peptide derivatives of the formula: Image wherein m is 0 or 1; n is 0 or an interger of 1 to 9; R is lower alkyl which may be substituted with hydroxyl, or aryl; R1 is hydrogen or acyl having an acyclic hydrocarbon group, the terminal of which may be substituted with a cyclic hydrocarbon group directly, via a carbonyl group or via an oxygen atom; provided that when R1 is hydrogen m is 1; R2 is hydrogen or lower alkyl which may form a ring by connecting its terminal with the .alpha.-nitrogen atom when n is 0, or hydrogen when n is an interger of 1 to 9; R3 is hydrogen or lower alkyl; R4 and R5 are each hydrogen or lower alkyl which may be substituted with hydroxyl or benzyloxyl; R6 is hydrogen or lower alkyl; R7 is alkyl which may be substituted with lower alkoxyl or aralkyl; R8 is hydrogen or lower alkyl; R9 is hydrogen, lower alkyl or aralkyl; and (D) and (L) each indicate configurations if their res- pective carbon atoms are asymmetric; or an acid addition salt thereof, have immunostimulatory activity.

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