Glucose-based compounds with affinity to p-selectin

Details Glucose-based compounds with affinity to p-selectin Glucose-based compounds with affinity to p-selectin

C - Chemistry, Metallurgy

07

H

C07H 15/04 (2006.01) A61K 31/70 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2501842

The present invention relates to certain glucose-based compounds that have an affinity to P-selectin. Further, the invention relates to the use of these glucose-based compounds for the preparation of pharmaceutical compositions for the treatment of disorders associated with P-selectin, to conjugates, pharmaceutical carriers and drug delivery systems comprising said compounds, and to a method for determining whether a compound is capable of binding to P- selectin.

Cette invention, qui a trait à des composés à base de glucose présentant une affinité pour la sélectine-P, concerne également l'usage qui est fait de ces composés pour préparer des compositions pharmaceutiques destinées à traiter des troubles liés à la présence de sélectine-P. Elle porte, en outre, sur des conjugués, des excipients pharmaceutiques et des systèmes contenant ces composés, permettant d'administrer des médicaments, ainsi que sur une méthode permettant d D déterminer si un composé est susceptible de se fixer à la sélectine-P.

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