Glucose isomerases having altered substrate specificity

C - Chemistry – Metallurgy – 12 – N

Patent

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195/139, 195/39,

C12N 9/92 (2006.01) C12N 9/00 (2006.01) C12P 19/24 (2006.01) C12P 41/00 (2006.01)

Patent

CA 2033657

A method for selecting amino acid residues is disclosed which upon replacement will give rise to an enzyme with an altered substrate specificity. New mutant glucose isomerases with an altered substrate specificity are provided according to this method. These altered properties are useful in starch degradation and in other sugar conversion reactions.

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