Glucose regulated gene

Details Glucose regulated gene Glucose regulated gene

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) C12N 15/11 (2006.01) C12N 15/86 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2314141

The invention is a human munc13 gene (Hmunc13) and protein from kidney and other cells which has an important role in cell signaling. This gene is regulated by glucose. Hmunc13 contributes to the renal and microvascular complications associated with hyperglycemia in diabetes mellitus, through a variety of mechanisms including Hmunc13 linked apoptosis. The invention also includes biologically functional equivalent nucleotide sequences and proteins. The invention also relates to methods of using these nucleic acid sequences and proteins in medical treatments and drug screening.

L'invention concerne un gène humain munc13 (Hmunc13), ainsi qu'une protéine du rein et d'autres cellules, dont le rôle est important dans la signalisation cellulaire. Le gène considéré est à régulation glucosique. Il contribue aux complications rénales et microvasculaires associées à l'hyperglycémie dans le diabète sucré, par une variété de mécanismes englobant l'apoptose liée au Hmunc13. L'invention concerne également des séquences nucléotidiques et des protéines tenant lieu d'équivalents fonctionnels du point de vue biologique. L'invention concerne en outre des procédés relatifs à l'utilisation desdites séquences et protéines dans le cadre des traitements médicaux et de la sélection des médicaments.

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