Glucose tolerance factor and method of making same

C - Chemistry – Metallurgy – 07 – D

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C07D 215/38 (2006.01) A61K 31/47 (2006.01) B01D 15/08 (2006.01) C07D 215/42 (2006.01) C07D 401/00 (2006.01)

Patent

CA 1282786

ABSTRACT OF THE DISCLOSURE A glucose tolerance factor which reduces blood sugar in mammals and is derived from yeast. The glucose tolerance factor can be isolated from autolyzed brewer's yeast extract by sequential fractionation on Sephadex* G-75, Biogel* P-6, and Biogel P-2, to give a purified glucose tolerance factor. By further purifi- cation, a substantially purified glucose tolerance factor is obtained which is a quinoline derivative with a molecular ion at 174 by mass spectrometry. *trade marks A3.2.txt 103186

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