Glucosylceramide synthase inhibition for the treatment of...

A - Human Necessities – 61 – K

Patent

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A61K 31/325 (2006.01) A61K 31/357 (2006.01) A61K 31/396 (2006.01) A61K 31/40 (2006.01) A61K 31/4025 (2006.01) A61K 31/403 (2006.01) A61K 31/4155 (2006.01) A61K 31/4178 (2006.01) A61K 31/4192 (2006.01) A61K 31/4245 (2006.01) A61K 31/427 (2006.01) A61K 31/428 (2006.01) A61K 31/4433 (2006.01) A61K 31/4439 (2006.01) A61K 31/453 (2006.01)

Patent

CA 2731685

A method of treating a glomerular disease selected from the group consisting of mesangial proliferative glomeru-lonephritis, collapsing glomerulopathy, proliferative lupus nephritis, crescentic glomerulonephritis and membranous nephropathy in a subject comprises administering to the subject an effective amount of a glucosylceramide synthase inhibitor.

L'invention concerne un procédé de traitement d'une maladie glomérulaire sélectionnée dans le groupe comprenant une glomérulonéphrite membranoproliférative, une glomérulopathie avec collapsus, une néphrite lupique proliférative, une glomérulonéphrite extracapillaire, et une néphropathie membraneuse chez un sujet, comprenant l'administration au sujet d'une quantité efficace d'un inhibiteur de synthase de glucosylcéramide.

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