Glucuronidated nebivolol_metabolites

C - Chemistry – Metallurgy – 07 – H

Patent

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Details

C07H 15/26 (2006.01) A61K 31/7048 (2006.01) A61K 45/06 (2006.01) A61P 9/00 (2006.01)

Patent

CA 2596428

This invention provides glucuronidated nebivolol metabolites and pharmaceutical compositions of glucuronidated nebivolol for treatment of cardiovascular diseases. In addition, this invention also provides compositions comprising nebivolol and/or at least one glucuronidated metabolite of nebivolol and/or at least one other active compound in a pharmaceutically acceptable carrier. This invention also provides methods of treating and/or preventing vascular diseases, by administering at least one glucuronidated metabolite of nebivolol that is capable of releasing a therapeutically effective amount of nitric oxide to a targeted site affected by the vascular disease.

La présente invention concerne des métabolites de nebivolol glycuroconjugués et des compositions pharmaceutiques de métabolites de nebivolol glycuroconjugués destinés au traitement de maladies cardio-vasculaires. Cette invention concerne aussi le nebivolol et/ou au moins un métabolite glycuroconjugué de nebivolol et/ou au moins un autre composé actif dans un porteur répondant aux normes pharmaceutiques. Cette invention concerne aussi des techniques de traitement et/ou de prévention de maladies vasculaires par administration d'une quantité thérapeutiquement efficace d'oxyde nitrique sur un site ciblé affecté par une maladie vasculaire. Cette invention concerne aussi le traitement et/ou la prévention de migraine par l'administration d'au moins un métabolite glycuroconjugué de nebivolol. Cette invention peut être utilisée avec un autre traitement ou sous forme de traitement unique de troubles de syndrome métabolique.

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