Glutaminyl based dpiv inhibitors

Details Glutaminyl based dpiv inhibitors Glutaminyl based dpiv inhibitors

C - Chemistry, Metallurgy

07

D

C07D 277/04 (2006.01) A61K 31/395 (2006.01) A61K 31/41 (2006.01) A61K 38/04 (2006.01) A61K 38/06 (2006.01) A61K 38/07 (2006.01) A61K 38/08 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) A61P 17/00 (2006.01) A61P 19/02 (2006.01) A61P 25/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07D 207/04 (2006.01) C07D 295/18 (2006.01) C07K 5/083 (2006.01) C07K 5/087 (2006.01) C07K 7/06 (2006.01)

Patent

CA 2479812

The present invention provides a compound of the formula (I): wherein X = CH2 or S or a pharmaceutically acceptable salt thereof. Such compounds and their corresponding pharmaceutically acceptable acid addition salt forms, are useful in treating conditions mediated by DPIV or DPIV-like enzymes, such as arthritis, obesity, immune and autoimmune disorders, allograft transplantation, cancer, neuronal disorders and dermal diseases.

La présente invention concerne des composés de formule (I), dans laquelle X = CH¿2? ou S, ou un sel pharmaceutiquement acceptable de ces composés. Lesdits composés et leurs sels d'addition d'acide pharmaceutiquement acceptables correspondants sont utiles pour traiter des maladies ou des états médiés par des enzymes DPIV ou de type DPIV, tels que l'arthrite, l'obésité, les maladies immunes et auto-immunes, les allogreffes, le cancer, les troubles du système nerveux et les maladies de la peau.

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