C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 5/037 (2006.01) A61K 47/48 (2006.01) C07K 5/00 (2006.01) C07K 5/02 (2006.01) C07K 17/00 (2006.01) C12N 9/10 (2006.01) C12Q 1/48 (2006.01)
Patent
CA 2105492
Compounds of the formula (see formula 1) or the alkyl(1-6C) or arylalkyl (7-12C) amides, alkyl(1-6C) or arylalkyl (7-12C) esters or salts thereof; wherein n is 1 or 2; wherein when n is 1, X is a mono- or disubstituted or unsubstituted hydrocarbyl(1-20C) moiety optionally containing 1 or 2 nonadjacent heteroatoms (O, S or N), and wherein said substitution is selected from the group consisting of halo, OR, and SR, wherein R is H or lower alkyl(1-4C); and wherein, when n is 2, one X is as above defined and the other X is lower alkyl(1-4C); Y is (see formula 2, 3, 4) or (see formula 5); and wherein n is 1 or 2, AA c is alanine, 4-aminobutyric acid, aspartic acid, phenylglycine, histidine, tryptophan or tyrosine wherein the phenyl group of phenyl-alanine or phenylglycine may optionally contain a single substitution by halo, -OR, or -SR where R is H or alkyl (1-4C)coupled through a peptide bond to the remainder of the compound of Formula (1), -49- are useful as affinity ligands and elution reagents and as diagnostic reagents. These compounds and analogous tripeptide glutathione analogs can be used as members of panels to obtain specific characteristic profiles for various glutathione-S-transferases.
Kauvar Lawrence M.
Lyttle Matthew H.
Fetherstonhaugh & Co.
Telik Inc.
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