C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/54 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07H 21/02 (2006.01) C07K 16/40 (2006.01) C12N 9/10 (2006.01) C12Q 1/48 (2006.01) G01N 33/50 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2270910
Complementary DNA and genomic clones for three variants of GST-.pi. are disclosed. It is demonstrated that certain of these variants are overexpressed in gliomas, thereby indicating an involvement with that form of cancer. This permits the detection and treatment of certain classes of tumors using new compositions such as GST-.pi. genes, oligonucleotides, peptides and antibodies.
On décrit de l'ADN complémentaire et des clones génomiques pour trois variants de GST-.pi.. Il est prouvé que certains de ces variants sont surexprimés dans des gliomes, et sont donc impliqués dans cette forme de cancer. On peut ainsi détecter et traiter certaines classes de tumeurs à l'aide de nouvelles compositions telles que des oligonucléotides, des peptides, des anticorps et des gènes GST-.pi..
Akande Olanike
Ali-Osman Francis
Antoun Gamil
Buolamwini John K.
Keller Charles
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Board Of Regents The University Of Texas System
The University Of Mississippi
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