Glutathione-s-transferase mu as a measure of drug resistance

Details Glutathione-s-transferase mu as a measure of drug resistance Glutathione-s-transferase mu as a measure of drug resistance

C - Chemistry, Metallurgy

12

Q

C12Q 1/48 (2006.01) C12Q 1/68 (2006.01) G01N 33/573 (2006.01)

Patent

CA 2084825

GLUTATHIONE-S-TRANSFERASE MU AS A MEASURE OF DRUG RESISTANCE ABSTRACT OF THE INVENTION It has been discovered that by determining or measuring a person's glutathione-s-transferase (GST) mu activity one can determine or measure the individual's resistance to drugs, particularly to chemotherapeutic drugs. Approximate- ly 50% of the human population exhibit substantially no GST mu activity, with the remaining 50% showing GST mu activity. This remaining 50% of the population accordingly, when treated with drugs, such as a chemotherapeutic drug for cancer therapy, show less effective response to the drug therapy than the other 50% of the population which have substantially no GST mu activity, since GST mu tends to deactivate drugs. Accordingly, a person having GST mu activity would exhibit drug resistance and would not benefit as much by or be as good a candidate for cancer chemotherapy as a person who has no GST mu activity.

Affiliated with

Also associated with

Rating

Glutathione-s-transferase mu as a measure of drug resistance does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Glutathione-s-transferase mu as a measure of drug resistance, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Glutathione-s-transferase mu as a measure of drug resistance will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-2077216