Glutathionylspermidine synthetase

Details Glutathionylspermidine synthetase Glutathionylspermidine synthetase

C - Chemistry, Metallurgy

12

N

C12N 9/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2274515

The present invention describes an enzyme showing glutathionylspermidine synthetase-activity and being distinct from known enzymes with similar activities in several physicochemical parameters, a novel process to isolate said enzyme from Crithidia fasciculata, tools for the production thereof in genetically transformed organisms, and its use as a molecular target for the discovery of trypanocidal drugs.

La présente invention porte sur une enzyme qui se caractérise par une activité de glutathionylspermidine synthétase, mais se distingue d'enzymes connues ayant une activité similaire par plusieurs paramètres physicochimiques, sur un nouveau procédé pour isoler cette enzyme de Crithidia fasciculata, sur des moyens de production de l'enzyme dans des organismes modifiés génétiquement et son utilisation en tant que cible moléculaire pour la mise au point de trypanocides.

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