Glycerin derivative and its pharmacological use

Details Glycerin derivative and its pharmacological use Glycerin derivative and its pharmacological use

C - Chemistry, Metallurgy

07

D

167/211, 260/290

C07D 213/56 (2006.01) A61K 31/44 (2006.01) C07D 213/40 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 413/12 (2006.01)

Patent

CA 1334753

A glycerin derivative having the following formula (I) or (I') and a pharmaceutically acceptable salt thereof are useful to treat diseases caused by the platelet activating factor. Image (I) Image (I') (wherein in formula (I), A is Image , Image Image , -NH-(CH2)q-R9 , -NH-(CH2)r-OR10, -NH-(CH2)sNHCONR11R12, Image , -NH-(CH2)uCONR14R15, -NH-(CH2)v-O-(CH2)w-O-(CH2)x-H, Image Image [where m is 0-6, R2, R3 and R4 are each H or alkoxy; p is 0-6; R5 is H, alkyl, cycloalkyl, cycloalkylalkyl, aryl or aralkyl; R6 is H, OH, alkyl, alkoxy, aryl, -COR7 (wherein R7 is alkyl, alkoxy or cycloalkyl), or -OCONHR8 (where R8 is H or alkyl); q is 0-6; R9 is aryl or heteroaryl; r is 0-6; R10 is alkyl; s is 0-20; R11 and R12 are each H or alkyl; t is 0-6; R13 is H or alkoxycarbonyl; u is 0-6; R14 and R15 are each H or alkyl or together form a ring; v, w and x are each 1-10; y is 0-6; R16 is H or alkyl; z is 0-6; a is 3 or 4; and D is O, S or NH]; B is alkyl or aralkyl; R1 is acyl; n is 0-3; G is 2-pyridyl; and in formula (I') A' is Image , Image or Image ; [where n', m' and p' are each 0-6, R1', R2' and R3' are each H or alkoxy] B' is alkyl or aralkyl; D' is -Y'-(CH2)q'-GI [where Y' is Image (wherein R4' is alkyl or -CONR5'R6', here R5' and R6' are each H or alkyl), Image (where Y' is 1-3 and R7' is acyl), Image or Image , q' is 0-3 and G' is Image or Image (where R9', R10' and R11' are each alkyl and X? is anion]).

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