Glycerol derivatives, their preparation and their...

C - Chemistry – Metallurgy – 07 – D

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C07D 413/14 (2006.01) C07D 261/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01) C07F 9/10 (2006.01) C07F 9/547 (2006.01) C07F 9/653 (2006.01) C07F 9/6539 (2006.01) C07F 9/6558 (2006.01)

Patent

CA 1314889

ABSTRACT OF THE DISCLOSURE Glycerol derivatives having at least one heterocyclic group on the 3 or 2 position and a group of formula -Y-D-Q on the 1 position (in which Y represents oxygen, sulfur, -NR3-, -X-CO-R4-, -R4-CO-X-, -NR3-CO-, -CO-NR3- or -X-P(O)(OH)-O-, where -NR3- is optionally protected imino, R4 represents a direct bond or -NR3; and X represents oxygen or sulfur; D represents optionally substituted C1-C14 alkylene; and Q represents a nitrogen containing heterocyclic group or All amino group either or which is optionally quaternized) are PAF antagonists which may be used to treat asthma, inflammation and shock. They may be prepared by reacting a glycerol derivative having an active group at the 1-position with an appropriate compound to introduce the desired group.

529667

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