C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/87 (2006.01) A61K 31/21 (2006.01) A61K 31/70 (2006.01) A61K 47/18 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C07C 229/16 (2006.01) C07C 237/08 (2006.01) C07F 7/10 (2006.01) C07H 15/00 (2006.01) C07H 21/00 (2006.01) C07J 41/00 (2006.01) C12N 15/85 (2006.01)
Patent
CA 2251999
The invention concerns novel of compounds of formula (I) in which: R¿1? and R¿2?, identical or different are C¿6?-C¿23? alkyl or alkenyl radicals, linear or branched or -C(=O)-(C¿6?-C¿23?) alkyl or -C(=O)-(C¿6?-C¿23?) alkenyl, linear or branched. X is the oxygen atom or an amino -NR¿3? radical, R¿3? being a hydrogen atom or an inferior alkyl radical of 1 to 4 carbon atoms; n is a positive whole number from 1 to 6; m is a positive whole number from 1 to 6, and when n > 1, m can be identical or different. The invention also concerns novel compositions of said compounds and of active substances in particular therapeutically, comprising at least a negative charge for inserting said active substances in cells. It concerns in particular novel complexes, of which the active substance consists of one or several nucleic acids, useful for cell transfection.
L'invention concerne de nouveaux composés de formule (I) dans laquelle: R1 et R2 identiques ou différents sont des radicaux C6-C23 alkyle ou alcényle, linéaires ou ramifiés ou des radicaux -C(=O)-(C6-C23) alkyle ou -C(=O)-(C6- C23) alcényle, linéaires ou ramifiés. X est l'atome d'oxygène ou un radical amino -NR3, R3 étant un atome d'hydrogène ou un radical alkyle inférieur de 1 à 4 atomes de carbone; n est un nombre entier positif de 1 à 6; m est un nombre entier positif de 1 à 6; et lorsque n > 1, m peut être identique ou différent. Elle concerne également de nouveaux complexes de composés selon l'invention et de substances actives notamment thérapeutiquement, comportant au moins une charge négative permettant l'introduction desdites substances actives dans les cellules. Elle concerne notamment de nouveaux complexes, dont la substance active consiste en un ou plusieurs acides nucléiques, utiles pour transfecter les cellules.
Bischoff Rainer
Heissler Denis
Nazih Abdesslame
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Transgene S.a.
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