C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) C12N 1/15 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/00 (2006.01) C12N 9/02 (2006.01) C12N 15/85 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2418777
A glycerylaldehyde-3-phosphate dehydrogenase (GAPDH) promoter DNA and a method of screening an apoptosis inhibitor by using the same. According to the above method, an apoptosis inhibitor can be screened by assaying the promoter activity of GAPDH gene, which specifically expresses GAPDH protein inducing cell death in the process of cell death, by using host cells which have been transformed by a vector having the GAPDH promoter DNA integrated thereinto.
L'invention concerne un promoteur de déshydrogénase de glycérylaldhéhyde-3-phosphate (GAPDH) et une méthode de criblage d'un inhibiteur d'apoptose, ladite méthode utilisant ce promoteur. Selon la méthode susmentionnée, on peut cribler un inhibiteur d'apoptose en dosant l'activité du promoteur du gène GAPDH qui exprime spécifiquement la protéine GAPDH inductrice de la mort cellulaire au cours de l'apoptose, en utilisant des cellules hôtes qui ont été transformées par un vecteur pourvu du promoteur GAPDH intégré.
Ono Pharmaceutical Co. Ltd.
Riches Mckenzie & Herbert Llp
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