C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/36 (2006.01) A61K 31/495 (2006.01) A61P 25/18 (2006.01) C07D 241/04 (2006.01) C07D 243/08 (2006.01) C07D 295/14 (2006.01) C07D 333/20 (2006.01)
Patent
CA 2655159
The present invention provides compounds of formula (I) that are glycine transporter 1 (hereinafter referred to as GlyT-1) inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of GlyT1 such as cognitive disorders associated with Schizophrenia, ADHD (attention deficit hyperactivity disorder), MCI (mild cognitive impairment), and the like. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.
La présente invention concerne des composés qui sont des inhibiteurs du transporteur 1 de la glycine (ci-après désigné par GlyT1) et qui sont donc utiles pour le traitement de maladies pouvant être traitées par l'inhibition du GlyT1 telles que des troubles de la cognition associés à la schizophrénie, le trouble de déficit de l'attention/hyperactivité (Attention Deficit Hyperactivity Disorder ; ADHD), le trouble cognitif léger (Mild Cognitive Impairment ; MCI) et les maladies similaires. L'invention concerne également des compositions pharmaceutiques contenant de tels composés et des procédés de préparation de tels composés.
Amegadzie Albert
Harried Scott S.
Hitchcock Stephen
Qian Wenyuan
Xia Xiaoyang
Amgen Inc.
Gowling Lafleur Henderson Llp
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