Glycine transporter-transfected cells and uses thereof

Details Glycine transporter-transfected cells and uses thereof Glycine transporter-transfected cells and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 5/10 (2006.01) C07K 14/47 (2006.01) C12N 1/15 (2006.01) C12Q 1/02 (2006.01)

Patent

CA 2254835

The present invention relates to materials and methods for the identification of agents that regulate glycine transport in or out of cells, particularly in or out of neuronal and neuronal-associated cells. Such materials include non-mammalian cells having transfected therein a glycine transporter. The methods relate to the manipulation of such cells such that agents are identified that cause intake or outflow of glycine with respect to a given glycine transporter.

La présente invention concerne des matières et des procédés permettant d'identifier des agents qui régulent l'acheminement de la glycine dans et hors de cellules, notamment l'acheminement dudit produit dans des cellules neuronales ou des cellules associées aux neurones. Lesdites matières comprennent des cellules non mammifères dans lesquelles un transporteur de glycine est transfecté. Lesdits procédés décrivent la manière de manier lesdites cellules pour identifier des agents responsables de l'admission ou du rejet de la glycine en rapport avec un transporteur de glycine donné.

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