Glyco-engineered antibodies

Details Glyco-engineered antibodies Glyco-engineered antibodies

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) C07K 16/00 (2006.01) G01N 33/00 (2006.01)

Patent

CA 2657605

The present invention relates to an antibody preparation comprising modified antibodies of an animal or derivatives or fragments thereof, specific for an antigen, characterized in that ~ the antibodies or derivatives or fragments thereof comprise an N-glycan structure free of fucose and xylose, and ~ at least 90%, preferably at least 95%, more preferred at least 99%, most preferred at least 100% of the modified an tibodies, derivatives or fragments thereof lack a C-terminal lysine residue.

La présente invention concerne une préparation d'anticorps comprenant des anticorps animaux modifiés spécifiques d'un antigène, des dérivés ou des fragments de ces anticorps et caractérisée en ce que les anticorps, leurs dérivés ou leurs fragments contiennent une structure N-glycane sans fucose ni xylose et en ce qu'au moins 90 %, de préférence au moins 95 %, de préférence au moins 99 % ou de préférence au moins 100 %, des anticorps modifiés, leurs dérivés ou fragments ne présentent aucun résidu de lysine C-terminal.

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