Glycoalkaloids for controlling cellular autophagy

C - Chemistry – Metallurgy – 12 – Q

Patent

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Details

C12Q 1/02 (2006.01) A61K 31/20 (2006.01) A61K 31/565 (2006.01) A61K 31/57 (2006.01) A61K 31/58 (2006.01) A61K 38/19 (2006.01) A61K 38/27 (2006.01) A61K 38/28 (2006.01) A61K 49/00 (2006.01) C07J 43/00 (2006.01) C07J 71/00 (2006.01) C07J 73/00 (2006.01) G01N 33/50 (2006.01) G01N 33/532 (2006.01) G01N 33/569 (2006.01) G01N 33/574 (2006.01) G01N 33/74 (2006.01) A61K 31/705 (1990.01) A61K 49/02 (1990.01)

Patent

CA 2073855

The invention is directed to the control of cellular autophagy, cellular agglutination and the immobilization of motile cells. Such control is useful in, for example, the treatment of cancer, contraception, termination of pregnancy, removal of pathogenic organisms and removal of any abnormal cellular growth (malignant or otherwise); as a diagnostic and analytical tool whereby cell structure can be studied and testing could be undertaken for the presence (and subsequent analysis) of pathogenic and non-pathogenic organisms; and in the manufacture of biochemicals whereby certain cells must be destroyed or otherwise contained. From surface analysis of normal and abnormal cells, specific receptors on abnormal cells which are either not present on normal cells or are only present insignificantly reduced numbers can be identified. Alkaloids and other pharmaceutically acceptable compounds are preferentially recognised by the abnormal cells, and which bind thereto and subsequently destroy.

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