A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01) A61K 39/112 (2006.01) A61K 39/385 (2006.01) A61P 31/04 (2006.01) A61P 37/04 (2006.01) C07H 3/06 (2006.01)
Patent
CA 2689524
The present invention relates to compounds derived from sugars which reproduce the epitopes of Shigella flexneri serotypes 3a and X and to the use thereof for the preparation of vaccine compositions. More specifically, the subject matter of the present invention relates to novel glycoconjugated compounds comprising oligosaccharides or polysaccharides described hereinafter, to the method for synthesizing these oligosaccharides or polysaccharides and glycoconjugates, to derivatives of these oligosaccharides or polysaccharides, to compositions containing same, and also to the use of the glycoconjugates for vaccination purposes. Finally, the present invention relates to methods for diagnosing a Shigella flexneri infection using one or more oligosaccharides or polysaccharides or conjugates thereof.
La présente invention se rapporte à des composés dérivés de sucres reproduisant les épitopes des sérotypes 3 a et X de Shigella flexneri et à leur utilisation pour la préparation de compositions vaccinales. Plus spécifiquement, l'objet de la présente invention se rapporte à de nouveaux composés glycoconjugués comprenant des oligo- ou polysaccharides décrits ci-après, au procédé de synthèse de ces oligo- ou polysaccharides et glycoconjugués, à des dérivés de ces oligo- ou polysaccharides, à des compositions les contenant, ainsi qu'à l'utilisation des glycoconjugués à des fins de vaccination. La présente invention se rapporte enfin à des méthodes de diagnostic d'une infection de Shigella flexneri utilisant un ou plusieurs oligo- ou polysaccharides ou leur conjugués.
Boutet Julien
Guerreiro Catherine
Mulard Laurence
Nato Farida
Phalipon Armelle
Centre National de La Recherche Scientifique
Institut Pasteur
Robic
Universite Paris Descartes
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