Glycoconjugates from modified camptothecin derivates...

Details Glycoconjugates from modified camptothecin derivates... Glycoconjugates from modified camptothecin derivates...

C - Chemistry, Metallurgy

07

H

C07H 17/00 (2006.01) A61K 31/70 (2006.01) C07D 491/22 (2006.01) C07H 15/20 (2006.01) C07H 15/26 (2006.01) C07K 5/068 (2006.01) C07K 5/078 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2267328

Disclosed are glycoconjugates from modified camptothecin derivates, where at least a glucidic component is linked to the 20-hydroxyl group of a camptothecin derivate. Also disclosed are their preparation and their use as pharmaceutical products, especially against cancer diseases.

La présente invention concerne les glycoconjugués à base de dérivés modifiés de camptothécine, où au moins un composant glucide est lié au groupe hydroxyl-20 d'un dérivé de camptothécine. Elle porte aussi sur le mode de préparation des composés et leur utilisation en tant que produits pharmaceutiques, notamment contre les maladies du cancer.

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