Glycoconjugates of modified camptothecin derivatives (a- or...

Details Glycoconjugates of modified camptothecin derivatives (a- or... Glycoconjugates of modified camptothecin derivatives (a- or...

C - Chemistry, Metallurgy

07

K

C07K 5/068 (2006.01) A61K 38/05 (2006.01) A61K 47/48 (2006.01) C07K 9/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2267493

The invention concerns glycoconjugates of camptothecin derivatives in which at least one carbohydrate component is linked via suitable spacers to the A- or B- ring of a camptothecin derivative. The invention further concerns processes for preparing the compounds according to the invention, and their use as medicaments, in particular for use in conjunction with cancers.

L'invention concerne des composés glyco-conjugués de dérivés de camptothécine, dans lesquels au moins un composant hydrate de carbone est lié au cycle A ou B d'un dérivé de camptothécine par l'intermédiaire d'espaceurs et de séquences intercalaires appropriés. L'invention concerne en outre un procédé de fabrication des composés précités, ainsi que leur utilisation comme médicaments pour lutter contre le cancer.

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