C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/18 (2006.01) C07K 16/30 (2006.01) G01N 33/577 (2006.01)
Patent
CA 2753713
Compositions and methods for diagnosing ovarian cancer in a patient and for identifying patients with an increased likelihood of having ovarian cancer are provided. The compositions include novel monoclonal antibodies, and variants and fragments thereof, that specifically bind to glycodelin. Monoclonal antibodies having the binding characteristics of a glycodelin antibody of the invention and monoclonal antibodies that bind to a glycodelin epitope of a disclosed antibody are further provided. Hybridoma cell lines that produce a glycodelin monoclonal antibody of the invention are also disclosed herein. The compositions find use in diagnostic methods as well as in screening methods for identifying patients having an increased likelihood of having ovarian cancer. Kits comprising one or more of the disclosed glycodelin monoclonal antibodies and for practicing the methods of the invention are further provided. Polypeptides comprising the amino acid sequence for a glycodelin epitope of a disclosed monoclonal glycodelin antibody and methods of using these polypeptides in the production of glycodelin antibodies are also encompassed by the present invention.
L'invention concerne des compositions et des procédés permettant de diagnostiquer le cancer de l'ovaire chez un patient et d'identifier les patients présentant une probabilité accrue d'avoir un cancer de l'ovaire. Les compositions comportent de nouveaux anticorps monoclonaux, ainsi que des variants et fragments de ceux-ci, qui se lient spécifiquement à la glycodéline. L'invention concerne en outre des anticorps monoclonaux présentant des caractéristiques de liaison à un anticorps de la glycodéline selon l'invention et des anticorps monoclonaux qui se lient à un épitope de la glycodéline d'un anticorps. L'invention concerne également des lignées cellulaires d'hybridome qui produisent un anticorps monoclonal de glycodéline selon l'invention. Les compositions peuvent servir dans des procédés de diagnostic ainsi que dans des procédés de criblage pour identifier des patients présentant une probabilité accrue d'avoir un cancer de l'ovaire. L'invention concerne en outre des trousses comprenant un ou plusieurs anticorps monoclonaux de la glycodéline selon l'invention et pour l'exercice des procédés selon l'invention. L'invention concerne enfin des polypeptides comprenant la séquence d'acides aminés d'un épitope de la glycodéline de l'anticorps de la glycodéline monoclonal et des procédés d'utilisation de ces polypeptides dans la production d'anticorps de la glycodéline.
Cheek Robert L.
Dixon Eric P.
Fischer Timothy J.
Groelke John W.
Knapp Steven L.
Smart & Biggar
Tripath Imaging Inc
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