Glycogen synthase kinase-3 inhibitors

Details Glycogen synthase kinase-3 inhibitors Glycogen synthase kinase-3 inhibitors

C - Chemistry, Metallurgy

07

F

C07F 9/6518 (2006.01) A61K 31/661 (2006.01) A61K 31/675 (2006.01) A61P 3/10 (2006.01) C07F 9/09 (2006.01)

Patent

CA 2587732

Novel compounds designed to allow interactions with binding sites of GSK-3 and hence are capable of inhibiting GSK-3 activity, via inhibition of substrate binding are disclosed. Further disclosed are pharmaceutical compositions including same and methods of using same in the treatment of GSK-3 mediated conditions.

La présente invention a trait à de nouveaux composés destinés à permettre des interactions avec des sites de liaison de la GSK-3 et donc capables d'inhibition de l'activité de la GSK-3, grâce à l'inhibition de liaison de substrat. L'invention a également trait à des compositions pharmaceutiques comportant de tels composés et à des procédés d'utilisation de tels composés dans le traitement de conditions médiées par la GSK-3.

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