Glycol linked fgf-21 compounds

Details Glycol linked fgf-21 compounds Glycol linked fgf-21 compounds

C - Chemistry, Metallurgy

07

K

C07K 14/50 (2006.01) A61K 38/18 (2006.01) A61P 3/00 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) C07K 17/00 (2006.01)

Patent

CA 2557782

The invention provides FGF-21 compounds covalently attached to at least one polyethylene glycol molecule or derivative thereof, resulting in a biologically active polypeptide with an extended elimination half-life and a slower clearance when compared to that of non-PEGylated polypeptide. These PEGylated FGF-21 compounds and compositions are useful in treating diabetes, obesity, and metabolic syndrome.

La présente invention concerne des composés FGF-21 qui sont liés par covalence à au moins une molécule de polyéthylène glycol ou à un dérivé de ce dernier, ce qui produit un polypeptide biologiquement actif à demi-vie d'élimination étendue et à clairance plus lente comparativement à celles d'un polypeptide non lié au polyéthylène glycol. Ces composés FGF-21 liés au polyéthylène glycol et les compositions correspondantes sont utiles dans le traitement du diabète, de l'obésité et du syndrome métabolique.

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