Glycolipid enzyme-polymer conjugates

Details Glycolipid enzyme-polymer conjugates Glycolipid enzyme-polymer conjugates

C - Chemistry, Metallurgy

12

N

C12N 9/96 (2006.01) A61K 38/46 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) C12N 9/24 (2006.01) C12N 11/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2150956

Conjugates having activity against gylcolipids such as glucocerebroside and non-antigenic polymers such as polyethylene glycol are disclosed. The conjugates circulate for extended times and have prolonged activity in vivo when compared to unmodified enzymes. The conjugates are useful in the treatment of Gaucher's disease.

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