Glycomimetic antagonists for both e- and p-selectins

Details Glycomimetic antagonists for both e- and p-selectins Glycomimetic antagonists for both e- and p-selectins

C - Chemistry, Metallurgy

07

H

C07H 15/18 (2006.01) A61K 31/702 (2006.01) A61K 31/7042 (2006.01) A61K 31/7048 (2006.01) A61K 31/7056 (2006.01) A61K 31/706 (2006.01) A61P 37/06 (2006.01) C07H 3/06 (2006.01)

Patent

CA 2546784

Compounds and methods are provided for modulating in vivo and in vivo processes mediated by selectin biniding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g. inhibit or enhance) a selectin-mediated function comprise particular glycomimetics linked to a member of a class of compounds termed BASAs (Benzyl Amino Sulfonic Acids).

L'invention concerne des composés et des méthodes permettant de moduler des procédés in vivo et in vivo dont la médiation est assurée par la liaison à la sélectine. L'invention concerne plus particulièrement des modulateurs de sélectine et leur utilisation. Ces modulateurs qui modulent (c'est-à-dire, qui inhibent ou augmentent) une fonction dont la médiation est assurée par la sélectine comprennent des glycomimétiques particuliers reliés à un élément d'une classe de composés dénommés BASA (Benzyl Amino Sulfonic Acids).

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