Glycopegylated factor ix

Details Glycopegylated factor ix Glycopegylated factor ix

C - Chemistry, Metallurgy

12

N

C12N 9/64 (2006.01) A61K 38/48 (2006.01) A61K 47/48 (2006.01) A61P 7/04 (2006.01) C12N 9/96 (2006.01)

Patent

CA 2549413

The present invention provides conjugates between Factor IX and PEG moieties. The conjugates are linked via an intact glycosyl linking group interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from glycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto a glycosyl residue on the peptide. Also provided are methods for preparing the conjugates, methods for treating various disease conditions with the conjugates, and pharmaceutical formulations including the conjugates.

L'invention concerne des conjugués entre le Facteur IX et des fractions de PEG. Les conjugués sont liés par le biais d'un groupe de liaison glycosyl intact placé entre le peptide et le groupe de modification auxquels il est fixé de manière covalente. Les conjugués sont formés à base de peptides glycosylés par l'action d'une glycosyltransférase. Cette dernière ligature une fraction de sucre modifiée à un résidu glycosyl sur le peptide. L'invention concerne en outre des procédés de préparation de ces conjugués, des procédés de traitement de divers états pathologiques avec ces conjugués, et des formulations pharmaceutiques comprenant ces conjugués.

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