C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/535 (2006.01) A61K 38/22 (2006.01) A61K 47/48 (2006.01) A61P 31/00 (2006.01) C07K 1/113 (2006.01) C07K 17/08 (2006.01) C12P 21/02 (2006.01)
Patent
CA 2549409
The present invention provides conjugates between Granulocyte Colony Stimulating Factor and PEG moieties. The conjugates are linked via an intact glycosyl linking group that is interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from both glycosylated and unglycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto either an amino acid or glycosyl residue on the peptide. Also provided are pharmaceutical formulations including the conjugates. Methods for preparing the conjugates are also within the scope of the invention.
L'invention porte sur des conjugués de facteur de stimulation de colonies de granulocytes (Granulocyte Colony Stimulating Factor) et de fragments de PEG. Lesdits conjugués sont reliés par l'intermédiaire d'un groupe de liaison de glycosyle intact interposés, et liés par covalence au peptide et au groupe modificateur, et produits à partir de peptides glycosylés ou non sous l'action de la glycosyltransférase. La glycosyltransférase fixe un fragment de sucre modifié soit sur un acide aminé, soit sur le résidu glycosyle du peptide. L'invention porte également sur des préparations pharmaceutiques contenant lesdits conjugués, et sur leur procédé d'obtention.
Bowe Caryn
Clausen Henrik
Defrees Shawn
Schwartz Marc
Wang Zhi-Guang
Biogenerix Ag
Gowling Lafleur Henderson Llp
Neose Technologies Inc.
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