Glycopeptide antibiotic and semisynthetic derivatives...

A - Human Necessities – 61 – K

Patent

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A61K 38/14 (2006.01) C07K 9/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2497159

Novel glycopeptide antibiotic derivatives, processes for their preparation, their use as a medicine, their use to treat or prevent viral infections and their use to manufacture a medicine to treat or prevent viral infections are provided. The present invention relates to the use of glycopeptide antibiotics and their semisynthetic derivatives to treat or prevent viral infections and their use to manufacture a medicine to treat or prevent viral infections of subjects, more in particular infections with viruses belonging to Retroviridae, Herpes viridae, Flaviviridae and the Coronaviridae, like HIV (human immunodeficiency virus), HCV (hepatitis C virus), BVDV (bovine viral diarrhoea virus), SARS (severe acute respiratory syndrome) causing virus, FCV (feline coronavirus), HSV (herpes simplex virus), VZV (varicella zoster virus) and CMV (cytomegalovirus).

L'invention concerne de nouveaux dérivés antibiotiques de glycopeptides, des méthodes servant à les préparer, leur utilisation sous forme de médicament, leur utilisation pour traiter ou prévenir des infections virales et leur utilisation pour préparer un médicament servant à traiter ou à prévenir des infections virales. Elle concerne l'utilisation d'antibiotiques de glycopeptides et leurs dérivés semi-synthétiques afin de traiter ou de prévenir des infections virales et leur utilisation afin de préparer un médicament servant à traiter ou à prévenir des infections virales, plus particulièrement, des infections provoquées par des virus appartenant à Retroviridae, Herpes viridae, Flaviviridae et les Coronaviridae, tels que VIH (virus de l'immuno-déficience humaine), VHC (virus de l'hépatite C), BVDV (virus de la diarrhée virale des bovins), le virus provoquant le SARS (syndrome respiratoire aigu sévère), FCV (coronavirus félin), HSV (virus de l'herpès simplex), VZV (virus de la varicelle) et CMV (cytomégalovirus).

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