Glycopeptide antibiotics

Details Glycopeptide antibiotics Glycopeptide antibiotics

C - Chemistry, Metallurgy

07

K

530/15.14, 167/1

C07K 9/00 (2006.01) A61K 38/00 (2006.01) C12P 21/04 (2006.01)

Patent

CA 1339808

A82846-related glycopeptide compounds are prepared by treating an antibiotic selected from A82846 components A, B and C with trifluoroacetic acid to remove 1) the .alpha.-L-O-4-epi-vancosaminyl group attached to the disaccharide; 2) the (.alpha.-L-O-4-epi-vancosaminyl-.beta.-O-glucosyl) disaccharide group or 3) both the disaccharide group and the .alpha.-L-O-4-epi-vancosaminyl group attached to the peptide core from these antibiotics. The compounds have antibacterial activity, especially against Gram-positive microorganisms.

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