C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 9/00 (2006.01) A61K 38/14 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2251086
The present invention is directed to certain glycopeptide dimers in which two glycopeptide units are covalently linked to one another through their disaccharide amine, via a linking radical. This invention is also directed to the monomeric intermediates. All of these compounds are useful as antibacterials, especially for the control of gram positive bacteria; the compounds are particularly useful for the control of resistant bacterial strains, such as vancomycin-resistant- enterococci ("VRE").
La présente invention concerne certains dimères glycopeptidiques dans lesquels les deux unités glycopeptidiques sont liées l'une à l'autre par covalence au moyen de leur disaccharide amine via un radical de liaison. L'invention concerne également des intermédiaires monomères. Tous ces composés conviennent comme agents antibactériens, et particulièrement pour combattre une bactérie Gram positive; de tels composés conviennent particulièrement pour combattre les souches bactériennes résistantes telles que les entérocoques résistants à la vancomycine ou "VRE" (Vancomycin-Resistant-Enterococci).
Stack Douglas Richard
Thompson Richard Craig
Eli Lilly And Company
Fasken Martineau Dumoulin Llp
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