Glycopeptide constructs and uses thereof

Details Glycopeptide constructs and uses thereof Glycopeptide constructs and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 9/00 (2006.01) A61K 38/14 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2734348

Glycopeptide conjugates, and methods of making and using such conjugates are disclosed. Certain glycopeptide conjugates comprise tumor associated carbohydrate antigens and peptide epitopes. Certain glycopeptide conjugates comprise cyclic peptide scaffolds that display carbohydrate antigens in a clustered fashion. The immunogenicity of select glycopeptide con-jugates is demonstrated.

L'invention concerne des conjugués glycopeptidiques, et des procédés de fabrication et d'utilisation de tels conjugués. Certains conjugués glycopeptidiques comprennent des antigènes de glucide associés à une tumeur et des épitopes peptidiques. Certains conjugués glycopeptidiques comprennent des supports de peptide cyclique qui affichent des antigènes de glucide d'une manière agglomérée. L'immunogénicité de conjugués glycopeptidiques sélectionnés est démontrée.

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