C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/20 (2006.01)
Patent
CA 2558754
The invention relates to a glycopeptide comprising between 1 and 40 repeated C-terminal polypeptides, with 11 amino acids, of BSDL or FAPP, whereby the aforementioned polypeptides are glycosylated and bear glycosylated epitopes giving rise to a specific immunological reaction with induced antibodies in a patient suffering from type 1 diabetes, and/or purified from biological fluids of human or animal origin or recombinant and produced by expression in a standard host cell comprising an enzymatic material necessary for priming a glycosylation, said host cell being genetically modified such as to comprise a gene coding for the aforementioned polypeptides and a gene coding for one or more enzymes selected from among glycosyltransferases and anti-glycopeptide antibodies. The invention also relates to the applications thereof in therapeutics and diagnostics.
Glycopeptide comprenant de (1 à 40) polypeptides répétés C-terminaux, composés de (11) acides aminés, de la BSDL ou de la FAPP, lesdits polypeptides étant glycosylés et portant des épitopes glycosylés donnant lieu à une réaction immunologique spécifique avec des anticorps induits chez un patient atteint par un diabète de type I et ou bien purifié à partir de fluides biologiques d'origine humaine ou animale ou bien recombinant et pouvant être produit par expression dans une cellule-hôte conventionnelle comprenant un matériel enzymatique nécessaire à l'amorçage d'une glycosylation, ladite cellule-hôte étant génétiquement modifiée de manière à comporter un gène codant pour lesdits polypeptides et un gène codant pour une ou plusieurs enzymes choisies parmi les glycosyltransférases, anticorps anti-glycopeptide et applications en thérapeutique et diagnostic.
Bernard Jean-Paul
Lombardo Dominique
Mas Eric
Panicot-Dubois Laurence
Sadoulet Marie-Odile
Inserm (institut National de La Sante Et de La Recherche Medical
Robic
Universite de La Mediterranee
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