Glycoprotein ligand for p-selectin and methods of use thereof

Details Glycoprotein ligand for p-selectin and methods of use thereof Glycoprotein ligand for p-selectin and methods of use thereof

C - Chemistry, Metallurgy

12

N

C12N 15/64 (2006.01) A61K 38/17 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 15/12 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2151142

P-selectin has been demonstrated to bind primarily to a single glycoprotein ligand on neutrophils and HL-60 cells, when assessed by blotting assays and by affinity chromatography of [3H]glucosamine- labeled HL-60 cell extracts on immobilized P- selectin. This molecule was characterized and distinguished from other well- characterized neutrophil membrane proteins with similar apparent molecular mass. The purified ligand, or fragments thereof, including both the carbohydrate and pro- tein components, or antibodies to the ligand, or fragments or components thereof, can be used as inhibitors of binding of P-selectin to cells.

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