Glycoprotein synthesis

Details Glycoprotein synthesis Glycoprotein synthesis

C - Chemistry, Metallurgy

12

N

C12N 15/52 (2006.01) C07K 1/107 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 9/00 (2006.01) C12P 21/00 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2500653

Methods for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid into a protein and attaching one or more saccharide moieties to the unnatural amino acid. Another method involves incorporating an unnatural amino acid that includes a saccharide moiety into a protein. Proteins made by both methods can be further modified with additional sugars.

L'invention concerne des méthodes de production de glycoprotéines, à la fois, in vitro et in vivo. Une méthode consiste à incorporer un acide aminé non naturel dans une protéine et à attacher au moins un groupe caractéristique de saccharide à l'acide aminé non naturel. Une autre méthode consiste à incorporer un acide aminé non naturel qui comporte un groupe caractéristique de saccharide dans une protéine. Les protéines obtenues au moyen de ces deux méthodes peuvent être, ensuite, modifiées avec des sucres supplémentaires.

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