Glycoproteins having lipid mobilising properties and...

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/47 (2006.01) A61K 38/17 (2006.01) C07K 14/705 (2006.01) C07K 16/30 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2329138

A biologically active lipid mobilising agent for use in therapy is disclosed which has the properties and characteristics of a Zn-.alpha.2-glycoprotein, or of a fragment thereof having an apparent molecular mass M r greater than 6.0 kDa as determined by gel exclusion chromatography. Methods of isolation and purification from biological material are also disclosed together with uses of the material for making up pharmaceutical compositions, especially pharmaceutical compositions useful for treating mammals to achieve weight reduction or for controlling obesity. In addition, uses of the material for developing diagnostic agents and for identifying inhibitors of lipolytic activity for therapeutic purposes are disclosed.

La présente invention concerne un agent de mobilisation des lipides bioactif pouvant être utilisé en thérapie, qui est doté des propriétés et caractéristiques d'une Zn-.alpha.¿2?-glycoprotéine ou d'un fragment de celle-ci possédant une masse moléculaire apparente supérieure à 6,0 kDa telle que mesurée par filtration sur gel. L'invention se rapporte à des procédés d'isolement et de purification de cette glycoprotéine à partir de matières biologiques et à des utilisations de celle-ci dans la fabrication de compositions pharmaceutiques destinées, en particulier, au traitement de mammifères dans un but d'amaigrissement ou de lutte contre l'obésité. L'invention concerne enfin des utilisations de la glycoprotéine de l'invention dans la mise au point d'agents de diagnostic et dans l'identification d'inhibiteurs de l'activité lipolytique à des fins thérapeutiques.

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