Glycosaminoglycan-antagonising mcp-1 mutants and methods of...

Details Glycosaminoglycan-antagonising mcp-1 mutants and methods of... Glycosaminoglycan-antagonising mcp-1 mutants and methods of...

C - Chemistry, Metallurgy

07

K

C07K 14/52 (2006.01)

Patent

CA 2693063

Novel mutants of human monocyte chemoattractant protein 1 (MCP-1 ) with increased glycosaminoglycan (GAG) binding affinity and knocked-out or reduced GPCR activity compared to wild type MCP-1, and their use for therapeutic treatment of inflammatory diseases.

L'invention porte sur de nouveaux mutants de la protéine chimio-attractive monocytaire-1 (MCP-1) humaine, présentant une affinité de liaison accrue au glycosaminoglycan (GAG) et une activité GPCR neutralisée ou réduite par comparaison à la MCP-1 de type sauvage. L'invention porte également sur l'utilisation de ces mutants pour un traitement thérapeutique de maladies inflammatoires.

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