C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/52 (2006.01) A61K 38/19 (2006.01) C12N 15/12 (2006.01)
Patent
CA 2750983
Novel mutants of human monocyte chemoattractant protein 1 (MCP-1) with increased glycosamino-glycan (GAG) binding affinity and knocked-out or reduced GPCR activity compared to wild type MCP-1, and their use for therapeutic treatment of inflam-matory diseases.
La présente invention porte sur de nouveaux mutants de la protéine chimiotactique pour les monocytes humaine 1 (MCP-1) dotée d'une affinité de liaison accrue pour les glycosaminoglycanes (GAG) et d'une activité GPCR neutralisée ou réduite par comparaison avec la MCP-1 de type sauvage, et sur leur utilisation pour le traitement thérapeutique de maladies inflammatoires.
Protaffin Biotechnologie Ag
Sim & Mcburney
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