C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 17/10 (2006.01) A61K 31/727 (2006.01) A61K 38/57 (2006.01) A61K 47/48 (2006.01) A61L 27/00 (2006.01) A61L 27/20 (2006.01) A61L 29/00 (2006.01) A61L 31/00 (2006.01) A61L 33/00 (2006.01) C07K 14/81 (2006.01) C08B 37/00 (2006.01)
Patent
CA 2237159
Novel conjugates of glycosaminoglycans, particularly heparin and dermatan sulfate, and amine containing species and therapeutic uses thereof are described. In particular, mild methods of conjugating heparins to proteins, such as antithrombin III and heparin cofactor II, which provide covalent conjugates which retain maximal biological activity are described. Uses of these conjugates to prevent thrombogenesis, in particular in lung airways, such as found in infant and adult respiratory distress syndrome and on surfaces in contact with blood are also described.
L'invention concerne de nouveaux conjugués de glycosaminoglycanes, notamment l'héparine et le dermatane sulfate, ainsi que des espèces contenant des amines et leurs utilisations thérapeutiques. L'invention concerne notamment des procédés doux de conjugaison d'héparines à des protéines, tels que l'antithrombine III et le co-facteur II de l'héparine, permettant d'obtenir des conjugués covalents conservant une activité biologique maximale. L'invention concerne en outre les utilisations de ces conjugués dans la prévention de la thrombogénèse, notamment dans les voies aériennes des poumons, telle qu'on la rencontre dans le syndrome de détresse respiratoire aiguë chez l'enfant et l'adulte, et sur des surfaces au contact du sang.
Andrew Maureen
Berry Leslie
Hamilton Civic Hospitals Research Development Inc.
Mccarthy Tetrault Llp
Mcmaster University
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