Glycosaminoglycan-dnase combination therapy

Details Glycosaminoglycan-dnase combination therapy Glycosaminoglycan-dnase combination therapy

A - Human Necessities

61

K

A61K 38/46 (2006.01) A61K 9/00 (2006.01) A61K 31/726 (2006.01) A61K 31/727 (2006.01) A61K 31/728 (2006.01) A61K 31/737 (2006.01) A61K 47/36 (2006.01) A61P 11/12 (2006.01)

Patent

CA 2516322

A method of improving the efficacy of the treatment with a DNase of a subject having a disorder characterised by the presence of endogenous extracellular DNA, comprises : (a) administering to the subject a glycosaminoglycan or a physiologically acceptable salt thereof, the glycosaminoglycan or salt having an average molecular weight of from 8 to 40kd to the subject; and (b) administering DNase to the subject.

Une méthode permettant d'améliorer l'efficacité du traitement avec une DNase chez un individu atteint d'un trouble caractérisé par la présence d'ADN extracellulaire endogène consiste à: (a) administrer à l'individu un glycosaminoglycane ou un sel physiologiquement acceptable de ce dernier, le glycosaminoglycane ou son sel ayant un poids moléculaire moyen compris entre 8 et 40kd; et (b) à administrer à l'individu la DNase.

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