Glycosaminoglycans derived from the k5 polysaccharide having...

Details Glycosaminoglycans derived from the k5 polysaccharide having... Glycosaminoglycans derived from the k5 polysaccharide having...

C - Chemistry, Metallurgy

08

B

C08B 37/10 (2006.01) A61K 31/715 (2006.01) A61K 31/727 (2006.01) C08B 37/00 (2006.01)

Patent

CA 2404478

Glycosaminoglycans derived from the K5 polysaccharide having high anticoagulant and antithrombotic activity obtained by a process comprising the preparation of the K5 polysaccharide from Escherichia coli, N-deacetilation/N- sulfation, C-5 epimerization, supersulfation, selective O-desulfation, selective 6-O sulfation and N-sulfation, wherein said epimerization is carried out using the glucuronosyl C-5 epimerase enzyme in solution or in immobilized form in presence of specific divalent cations.

L'invention concerne des glycosaminoglycanes dérivés du polysaccharide K5 à forte activité anticoagulante et antithrombotique, dont la fabrication résulte du procédé suivant: élaboration du polysaccharide K5 à partir de l'Escherichia coli, N-désacétylation/N-sulfatation, C-5 épimérisation, supersulfatation, O-désulfatation sélective, 6-O sulfatation et N-sulfatation sélective, sachant que l'épimérisation est conduite avec l'enzyme glucuronosyle C-5 épimérase en solution ou sous forme immobilisée en présence de cations divalents spécifiques.

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