Glycosaminoglycans in the treatment of diabetic nephropathy...

A - Human Necessities – 61 – K

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A61K 31/725 (1995.01)

Patent

CA 2066785

The object of the present invention is the manufacture of a medicine for the use of glycosaminoglycans in the prevention and treatment of some pathologies caused by diabetes, like diabetic nephropathy and diabetic neuropathy. The effectiveness of glycosaminoglycans in the prevention and treatment of said pathologies has been shown by the treatment with some glycosaminoglycans of male albino rats made diabetic by treatment with streptozotocin or alloxan and by the subsequent determination of morphologic and clinic parameters like the thickness of the glomerular basal membrane, the number of the glomerular anionic charges and albuminuria in case of diabetic nephropathy, and like the levels of substance P and Met-Enkephalin in some intestinal zones, like duodenum and jejunum, in case of diabetic neuropathy.

L'invention concerne la fabrication d'un médicament à base de glycosaminoglycannes dans la prévention et le traitement de certaines pathologies causées par le diabète, comme la néphropathie et la neuropathie diabétiques. L'efficacité des glycosaminoglycannes dans la prévention et le traitement de ces pathologies a été démontrée par le traitement avec des glycosaminoglycannes de rats albinos rendus diabétiques par le traitement avec la streptozotocine ou l'alloxane et par la détermination subséquente de paramètres morphologiques et cliniques comme l'épaisseur de la membrane basale des capillaires du glomérule, le nombre de charges anioniques dans les glomérules et l'albuminurie dans le cas de la néphropathie diabétique, ainsi que les teneurs en substance P et en Met-enképhaline dans certaines parties de l'intestin, comme le duodénum et le jéjunum, dans le cas de la neuropathie diabétique.

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