Glycosolated enkephalin agents

Details Glycosolated enkephalin agents Glycosolated enkephalin agents

C - Chemistry, Metallurgy

07

K

C07K 14/665 (2006.01) A61K 38/14 (2006.01) A61K 38/33 (2006.01) A61P 25/04 (2006.01) C07K 7/00 (2006.01) C07K 7/06 (2006.01) C07K 9/00 (2006.01)

Patent

CA 2507527

It is taught here that enkephalin peptides which are glycosylated with a disaccharide will be transported across the blood brain barrier and deliver analgesic effects superior to morphine when introduced into the bloodstream. Glycosylated peptides with disaccharides attached are superior to analogous peptides with either mono- or tri- saccharides attached.

La présente invention enseigne que les peptides encéphaliniques glycosylés par un disaccharide seront transportés d'un côté à l'autre de la barrière hémato-encéphalique de manière à avoir une meilleure action analgésique que celle de la morphine lorsqu'ils sont introduits dans le débit sanguin. Les peptides glycosylés portant des disaccharides sont meilleurs que les peptides analogues portant des mono- ou trisaccharides.

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