C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 15/26 (2006.01) A61K 38/43 (2006.01) A61K 47/48 (2006.01) C07H 17/04 (2006.01) C07H 23/00 (2006.01)
Patent
CA 2028086
- 1 - BEHRINGWERKE AKTIENGESELLSCHAFT HOE 89/B 039 - Ma 792 Dr. Ha/Sd Abstract of the disclosure Glycosyl-etoposide prodrugs, a process for the prepara- tion thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates The present invention relates to glycosyl-etoposide prodrugs, a process for the preparation thereof and the use thereof in combination with functionalized tumor- specific enzyme conjugates for treating cancers, and specifically relates to 4'-O-glycosyl-etoposides as prodrugs which can be cleaved by the action of tumor- specific enzyme conjugates to give cytotoxic active sub- stances, the liberated active substance being suitable, by reason of its cytostatic activity, for treating cancers.
Bosslet Klaus
Czech Jorg
Kolar Cenek
Sedlacek Hans H.
Seemann Gerhard
Behringwerke Aktiengesellschaft
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
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